Which transporter primarily mediates the absorption of non-heme iron in the duodenum?

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Multiple Choice

Which transporter primarily mediates the absorption of non-heme iron in the duodenum?

Explanation:
The main idea is how non-heme iron from the diet enters duodenal cells. After ferric iron is reduced to ferrous iron at the brush border, the apical transporter DMT1 carries Fe2+ into the enterocytes. Inside the cell, iron can be stored or exported by ferroportin across the basolateral membrane, where it is oxidized and handed off to transferrin in the blood. Among the options, DMT1 is the primary importer of dietary non-heme iron into the duodenal cells. Ferroportin serves as the export step, transferrin receptor handles uptake of iron from transferrin into cells (not from the gut lumen), and ZIP14 is not the main carrier for initial duodenal iron absorption.

The main idea is how non-heme iron from the diet enters duodenal cells. After ferric iron is reduced to ferrous iron at the brush border, the apical transporter DMT1 carries Fe2+ into the enterocytes. Inside the cell, iron can be stored or exported by ferroportin across the basolateral membrane, where it is oxidized and handed off to transferrin in the blood. Among the options, DMT1 is the primary importer of dietary non-heme iron into the duodenal cells. Ferroportin serves as the export step, transferrin receptor handles uptake of iron from transferrin into cells (not from the gut lumen), and ZIP14 is not the main carrier for initial duodenal iron absorption.

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