Which statements correctly describe the main glucose transporters in enterocytes and their localization?

• A. SGLT1 on the apical side cotransporting sodium and glucose; GLUT2 on the basolateral side; GLUT5 on the apical side for fructose
• B. GLUT2 on the apical side; SGLT2 on basal; GLUT1 for fructose
• C. SGLT1 on basolateral; GLUT2 on apical; GLUT5 on apical
• D. SGLT2 on apical; SGLT1 on basolateral; GLUT4 for glucose

Answer: (A)

Understanding how glucose and fructose cross the intestinal epithelium relies on where their transporters sit on the enterocyte.

SGLT1 sits on the apical (brush-border) membrane and uses the sodium gradient to actively co-transport glucose into the cell. Inside the cell, glucose exits across the basolateral membrane via GLUT2, entering the blood by facilitated diffusion. Fructose is taken up from the lumen by GLUT5 on the apical membrane and then also exits through the basolateral GLUT2 into the portal circulation.

This pattern—SGLT1 on the apical side, GLUT2 on the basolateral side, and GLUT5 on the apical side for fructose—aligns with the established intestinal glucose/fructose transport mechanism. Other statements describe transporters or localizations that don’t fit enterocyte physiology (such as SGLT2 or GLUT4, or wrong membrane placements).