Which region of the stomach contains G cells and mucous cells?

• A. Fundus and body.
• B. Pylorus.
• C. Antrum.
• D. Cardia.

Answer: (C)

Gastrin-producing cells and mucus-secreting glands are found together in the antral region of the stomach, the pyloric antrum. G cells are enteroendocrine cells that release gastrin in response to peptides, amino acids, stomach distension, and vagal signals. Gastrin then stimulates acid secretion by nearby parietal cells (indirectly via ECL cells) and helps coordinate digestion as the stomach prepares to empty. The mucous cells in this region line the mucosa of the pyloric glands, providing a protective mucus layer as digestion proceeds. In contrast, the fundus and body mainly house acid- and enzyme-secreting cells, while the cardia is richer in mucus-secreting glands but lacks the gastrin-secreting cells characteristic of the antrum.