In celiac disease, iron absorption is reduced due to villous atrophy in which sections?

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Multiple Choice

In celiac disease, iron absorption is reduced due to villous atrophy in which sections?

Explanation:
Iron absorption occurs primarily in the duodenum and proximal jejunum, where the mucosa provides the largest absorptive surface. In celiac disease, the immune reaction to gluten causes villous atrophy in this proximal small intestine, greatly reducing surface area and the number of absorptive enterocytes. With less surface to absorb iron, uptake declines, leading to iron deficiency. The distal ileum isn’t the main site for iron uptake (it handles B12 and bile acids), and the stomach or sigmoid colon contribute minimally to iron absorption, so damage there wouldn’t explain reduced iron uptake.

Iron absorption occurs primarily in the duodenum and proximal jejunum, where the mucosa provides the largest absorptive surface. In celiac disease, the immune reaction to gluten causes villous atrophy in this proximal small intestine, greatly reducing surface area and the number of absorptive enterocytes. With less surface to absorb iron, uptake declines, leading to iron deficiency. The distal ileum isn’t the main site for iron uptake (it handles B12 and bile acids), and the stomach or sigmoid colon contribute minimally to iron absorption, so damage there wouldn’t explain reduced iron uptake.

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